Bioanalytics Laboratory
Head: Dr. Giuseppe Raucci
The Bioanalytical Laboratory develops and validatesanalytical methods in compliance with GLP standards, based on HPLC/UPLC liquid chromatography methods associated with different types of detectors.
Classes of molecules:
- Chemically synthesised drugs (Small Drugs);
- Biological drugs (Protein Drugs);
- Hybrid drugs (Antibody Drug Conjugates).
Types of services offered:
- Analysis of biomolecules (proteins and peptides):
- Analysis of degradations and post-translational modifications;
- Analysis of the covalent structure: amino acid sequence, structure of the oligosaccharide component of glycoproteins.
- Analysis of contaminants of biotechnological products, associated with the product and associated with the process
- Proteomics analysis
- Identification of proteins;
- Label free quantization;
- Differential analysis (Differential Proteomics);
- PK and PD analysis
- Pharmacokinetic and toxicokinetic analysis of plasma samples;
- Biodistribution analysis in biological matrices;
- Analysis of metabolites as a function of different routes of administration.
- Other services
- Transfer and optimization of analytical methods.
- Support for drug formulation.
Main types of equipment in use:
- HPLC/UPLC technology (Thermo);
- Thermo triple quadrupole mass spectrometer, mod. Quantiva;
- Hybrid Quadrupole-Orbitrap mass spectrometer Thermo mod. Q Exactive.