Bioanalytics Laboratory

Head: Dr. Giuseppe Raucci

The Bioanalytical Laboratory develops and validatesanalytical methods in compliance with GLP standards, based on HPLC/UPLC liquid chromatography methods associated with different types of detectors.

Classes of molecules:

• Chemically synthesised drugs (Small Drugs);
• Biological drugs (Protein Drugs);
• Hybrid drugs (Antibody Drug Conjugates).

Types of services offered:

- Analysis of biomolecules (proteins and peptides):

• Analysis of degradations and post-translational modifications;
• Analysis of the covalent structure: amino acid sequence, structure of the oligosaccharide component of glycoproteins.

- Analysis of contaminants of biotechnological products, associated with the product and associated with the process

- Proteomics analysis

• Identification of proteins;
• Label free quantization;
• Differential analysis (Differential Proteomics);

- PK and PD analysis

• Pharmacokinetic and toxicokinetic analysis of plasma samples;
• Biodistribution analysis in biological matrices;
• Analysis of metabolites as a function of different routes of administration.

- Other services

• Transfer and optimization of analytical methods.
• Support for drug formulation.

Main types of equipment in use:

• HPLC/UPLC technology (Thermo);
• Thermo triple quadrupole mass spectrometer, mod. Quantiva;
• Hybrid Quadrupole-Orbitrap mass spectrometer Thermo mod. Q Exactive.