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    Biogem Service - GENETICALLY MODIFIED ANIMAL AND CELL MODELS

     Gene targeting and experimental embryology

    - Genetically Modified Cellular Models

    Genetically modified cell models are crucial tools in scientific research, used to better understand the functions of genes and their role in human diseases. These models are created by specifically altering the DNA of cells through techniques such as CRISPR/Cas9, gene targeting or viral vector transfection. Modifications may include the insertion, removal or mutation of genes, allowing researchers to analyze how these changes affect cellular processes, such as proliferation, differentiation and response to external stimuli. Genetically modified cell models are essential for studying complex diseases, developing new treatments and testing the efficacy of drugs in a controlled environment. These models offer a highly specific and reproducible system, helping to reduce the use of animal models and to promote a more ethical approach to biomedical research.

    - Genetically Modified Mouse Models

    Genetically modified mouse models are essential tools for biomedical research, as they allow us to study the functions of specific genes and their role in human diseases. These models are generated by altering the DNA of mice through techniques such as gene targeting or genome editing exploiting the homologous recombination in embryonic stem (ES) cells. Genetic modifications may include the insertion, removal or mutation of specific genes, making possible for researchers to observe the biological effects of these alterations. These genetically modified mice are crucial for understanding the mechanisms of complex diseases such as cancer, neurodegenerative diseases and rare genetic diseases. They also serve as platforms for the development and testing of new drugs and gene therapies, accelerating the advancement of personalized medicine. Due to their importance, genetically modified mouse models became a standard in preclinical research and are a bridge between basic research and clinical applications.

    Zebrafish Facility 

    The zebrafish (Danio Rerio) is the main vertebrate organism model, not belonging to the class of mammals, whose use was initially relevant for the study of developmental biology and subsequently of various human diseases, including cancer, and for the evaluation of the toxicity of various molecules. Its success derives from the possibility of using it in the study of complex processes such as those related to organogenesis. In the field of oncology, the use of zebrafish larvae is currently widespread in order to monitor the invasive, metastatic, and proliferative capacity of human tumor cells (xenograft models).

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    A fascinating journey into the history of Earth and life, told by authentic fossil finds, by suggestive reproductions, and by a set of technological devices, which allow visitors to get immersed in an unexpected multimedia reality, capable of capturing the attention of adults and young people. The “Quadrifera”, the Multimedia Pyramid, the Immersive Museum, the 7D Multimedia Room and the replica of the skeleton of an Allosaurus Fragilis in life size are the main parts of the exhibition, specifically designed to illustrate the origins of Earth and the evolution of life on it.
    The UIIP Biogem Program (University Industry Internship Program) is a ‘bridge’ between the world of education and that of companies. UIIP tends on the one hand to meet the training needs of IT companies, characterized by a constant search for talent and resources, with specific digital skills, and on the other hand provides young graduates who participate in courses (lasting 2/3 months ) practical skills to enter the labor market (on topics such as SAP, Analytcs, Web) and adequate soft skills (team working, public speaking, problem solving). The post UIIP courses placement rate is 95%.
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