Animal Facility

[...] the [Biogem] animal facility is outstanding. It was designed with much more foresight of the facility that houses my mice [...]. Biogem's animal facility is the best among those that I have seen in Europe. I hope the government scientific institutions understand

the peculiarities of your animal facility and want to continue to fund it [...]. I'm sure that your animal facility's productivity and excellence levels will be maintained thanks to the excellence of the researchers who work at Biogem.

The Biogem Animal Facility is organized into distinct areas on the basis of on the microbiological containment and / or the hosted species:

- Conventional Area, where both rats and mice are housed

- Specific Pathogen Free (SPF) area, where the mice are housed and managed through strict microbiological controls

-Gnotobiotics Area (Germ-free), for the housing of rodents used for the evaluation of the microbiota in the onset of human diseases

- GLP Area (Good Laboratory Practice), where the regulatory in vivo studies of the Biogem Test Center are carried out for the areas of toxicology, pharmaco- and toxicokinetics and biocompatibility

- Zebrafish area, for the housing of the zebrafish fish models in special aquarium tanks

- Rabbit area, for the housing of the lagomorph, whose use is managed with specific standard operating procedures.

The Biogem Animal Facility is allowed to use rodents, rabbits and zebrafish for biomedical research by the Ministry of Health with Ministerial Decree n 12/2016-UT dated 29 September 2016 according to D.Lgs. 26/2014 (March 14th, 2014), concerning the protection of animals used for scientific purposes. The Biogem Animal Facility is certified by the International Organization for Standardization (ISO 9001:2015) and the experimental activities are conducted following specific Standard Operative Procedures (SOPs) in order to manage, standardize and guide operators and, moreover, to ensure the animal welfare.

Biogem applies the 3Rs principles:

REFINEMENT, through the use of environmental of sophisticated technologies for the in vivo imaging; REDUCTION of the number of animals enrolled in experimental procedures; REPLACEMENT of animal models through the literature research and the preliminary in vitro studies.