ANIMAL MODELS CORE FACILITY (AMCF)
Supervisor: Prof. Mario De Felice, MD
Molecular Biology: Dr Pina Marotta, PhD; Dr. Nicola Antonino Russo, PhD.
Cell Biology: Dr. Marina Marotta; Dr. Carla Reale, PhD; Dr. Filomena Russo
Embryology: Dr. Luca Roberto
Zebrafish modelling: Dr. Immacolata Porreca, PhD
I. Transgenic Mice Service
Genetically modified mouse models are one of the most powerful tools in scientific areas such as cancer, drug discovery and development biology. Nowadays it is possible to remove, replace and insert any kind of sequence in the mouse genome. Biogem offers quality custom generation of a wide range of mouse models, via homologous recombination in embryonic stem (ES) cells, using a variety of advanced molecular biology technologies, enabling you to obtain the precise models you need.
Our services can be ordered together or individually depending on the investigator's needs. Moreover, we can generate chimeras also by performing microinjection of ES clones obtained by consortia such as KOMP and EUCOMM.
II. Zebrafish Service
During the last few decades, a unique set of properties has made the zebrafish a popular vertebrate model in various field of biology, ranging from developmental biology, human disease studies to environmental toxicology.
The Zebrafish Service provides expertise for transgenic lines and mutants generation and support for design and realization of toxicology studies with the zebrafish model.